General questions

What is Betrinac®?

Betrinac® is an exclusive mix of higher doses of Vitamin B6 (20mg), Vitamin B12 (1000 mcg), Folic Acid (800 mcg) and the anti-oxidant N-acetylcysteine (NAC) (600mg).

How does Betrinac® work?

Betrinac® is unique; it contains high doses of three B vitamins, AND an antioxidant (NAC) to reduce oxidative stress and lower blood levels of homocysteine. Vitamins B6, B12 and folic acid are essential for a healthy body. They help maintain a healthy nervous system and help brain performance and memory as you get older.

Who will benefit from taking Betrinac®?

Betrinac® is suitable for all adults, except pregnant or lactating women.

What is homocysteine?

Homocysteine is an amino acid that is turned into useful compounds by B vitamins in our body.  Oxidative stress and ageing deplete B vitamins, resulting in high blood levels of homocysteine.

What are the consequences of high homocysteine?

High blood levels of homocysteine are associated with an increased risk of memory loss ("mild cognitive impairment"), stroke and dementia, including Alzheimer's disease (See our About Betrinac section for more information).

What is NAC?

NAC is a natural product found in foods including peppers, asparagus and cucumber. NAC increases levels of glutathione, the body’s main antioxidant. Glutathione protects cells from harmful free radicals. NAC is often used to treat paracetamol poisoning and break up mucus in cystic fibrosis. It also has other beneficial properties (see reference 1 and 2 below).

Is Betrinac® safe?

The ingredients in Betrinac® are all within allowable regulatory limits, but higher than those found in most other vitamin supplements. These levels are chosen to ensure optimal effects, and are well tolerated. The dose of B6 may be associated with mild tingling of hands and feet. If you notice this, stop taking the tablet. Betrinac® is lactose and gluten free.

Can Betrinac® be taken with other medications for Alzheimer’s disease?

Yes. There are no known interactions between commonly used treatments for Alzheimer’s disease and vitamin B6, vitamin B12, folic acid and NAC. In a small trial, the response to certain drugs used in patients with Alzheimer’s disease was improved by the addition of folic acid (see reference 5 below).

How often should Betrinac® be taken?

You should take one tablet daily, with or without food.

Where can I find copies of medical literature to read more about Homocysteine?

The references below are a good starting point.


References:

(1) Demirkol, O., et al. Biologically Important Thiols in Various Vegetables and Fruits. J. Agric. Food Chem. 2004, 52, 8151-8154.

(2) Dean, O., et al. N-acetylcysteine in Psychiatry: Current Therapeutic Evidence and Potential Mechanisms of Action. J Psychiatry Neurosci 2011, 36(2):78-86.

(3) Smith, AD. et al., Homocysteine-Lowering by B vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: a Randomized Controlled Trial. PLoS One. (www.plosone.org), September 2010, Volume 5(9), e12244.

(4) de Jager, CA., et al. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry, 2012, 27(6), 592-600.

(5) Connelly, PJ. et al., A Randomised Double-Blind Placebo-Controlled Trial of Folic Acid Supplementation of Cholinesterase Inhibitors in Alzheimer's disease. Int J Geriatr Psychiatry. 2008 Feb;23(2):155-60.